Antimicrobials
Daptomycin

Daptomycin

Low
N/A
$150/day+

Spectrum of Activity

Dosing

General Information

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC>=2) and VRE including endovascular infection

Creatine kinase weekly

  • Myopathy including rhabdomyolysis
  • GI side effects common
  • Rash
  • Phlebitis
  • Increased INR

Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy)

  • Mandatory ID consult for use in AHS.
  • Higher doses used for endovascular infection.
  • Recommend Infectious Disease Consult.
  • Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.

Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane

Pregnancy category: B

Average serum half life: 9.0

CSF penetration: Poor

Lung penetration: Poor

Urine penetration: Therapeutic