Antimicrobials
Fluconazole

Fluconazole

Low
Excellent
IV-$15/d PO-$3/d

Dosing

General Information

Candida infections both mucocutaneous and invasive - i.e. Candidemia

Cryptococcus and Coccidioides infections

Antifungal prophylaxis in immunocompromised

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement

  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash
  • Alopecia
  • GI upset

Many via CYP450 - suggest review specific patient medications

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics

Risk when combining with other QTc prolonging medications

Antimicrobial class: Triazole antifungal, decreases ergosterol synthesis

Pregnancy category: C

Average serum half life: 20.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic