Antimicrobials
Azithromycin

Azithromycin

Medium
Moderate
IV-$9/d PO-$1/d

Dosing

General Information

  • Community acquired pneumonia
  • Pertussis
  • Upper respiratory tract infections
  • Chlamidial infections
  • Mycobacterial infections
  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients

Monitor QTc in patients with increased risk

Prolongation of QTc interval - Association with increased cardiovascular mortality in observational studies.

Prolonged half life may contribute to macrolide resistance

Other drugs that prolong QTc

Increases cyclosporine levels

May increase digoxin levels

Statins increased risk of rhabdomyolysis

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - i.e. Salmonella spp

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 68.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor