Antimicrobials
Voriconazole

Voriconazole

Low
Excellent
IV-$300 PO-$100

Dosing

General Information

Candida infections both mucocutaneous and invasive - i.e. Candidemia

Antifungal prophylaxis in immunocompromised

Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity (discuss with ID)

QTc interval in patients at elevated risk

Monitor hepatic profile

  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash - up to 20%
  • Visual disturbance
  • Fluorosis
  •  GI upset

CYP450 interactions ++

Other QTc prolonging agents

Recommend review of pt medications due to high frequency of significant interactions

Antimicrobial class: Triazole antifungal, second generation

Pregnancy category: D

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor