IV Once Daily Dosing
Single daily dosing is preferred as it is less toxic than multiple daily dosing regimens.
Serum Level: PRE level should be drawn just prior to next anticipated dose
Initial Level: Day 3
Targets:
Daily Dose: 7 mg/kg/day
Maximum Daily Dose: 360 mg/dose before levels
Dosing Frequency: IV divided q24h unless renal dysfunction when intervals should be extended and/or doses decreased
May consider IM if no IV access
Multiple Daily Dosing
Consult Pharmacy