Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

NA

Dosing

IV Dosing

Daily Dose: 240 mg/kg/day of piperacillin component

Maximum Daily Dose: 16 g/day of piperacillin component

Dosing Frequency: IV divided q6h

< 2 kg

  • 0 – 7 days: 150 mg/kg/day divided Q12h

  • > 7 days: 225 mg/kg/day divided Q8h

> 2 kg

  • 0 – 7 days: 225 mg/kg/day divided Q8h

  • >7 days: 300 mg/kg/day divided Q6h

General Information

First Line Indications

  • Suspected or confirmed infections due to P. aeruginosa
  • Empiric therapy for febrile neutropenia