Gentamicin - Neonatal Dosing

0 - 14 days: Traditional Dosing

  • <28 weeks GA: 3 mg/kg/dose Q24H

  • 29 - 36 weeks GA: 3.5 mg/kg/dose Q24H

> 14 days: Traditional Dosing

  • < 28 weeks corrected GA: 3 - 3.5 mg/kg/dose Q18H

  • > 29 weeks corrected GA: 3 - 3.5 mg/kg/dose Q12H

NOTE: For frequency adjustment due to renal dysfunction, consult clinical pharmacist.

0 - 7 days: Traditional dosing

  • 3 - 3.5 mg/kg/dose Q18H

> 7 days: Extended Interval Dosing

  • 5 mg/kg/dose Q24H

For neonates with suspected, possible or confirmed hypoxic ischemic events, fluid imbalance, possible or suspected renal thrombosis, congenital renal anomalies or any other conditions that may be associated with transient or prolonged renal dysfunction.

3 mg/kg/dose  x 1 dose

Pre Gentamicin level 24 hours after initial dose, if < 2.0  mg/L may repeat dose

Consult clinical pharmacist for further dosing interval recommendations

Traditional Dosing

  • Pre (0 - 30 minutes before dose): 0.5 - 2 mg/L

  • Post (30 minutes after end of a 30 minutes infusion): 5 - 10 mg/L

Extended Interval Dosing

  • Pre (0 - 30 min. before dose) : less than 0.6 mg/L