Clindamycin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

>$4/day (Oral)

Dosing

>2 kg

  • 0 - 7 days: 15 mg/kg/day IV divided Q8H

  • > 7 days: 20 mg/kg/day IV divided Q6H

1.2 - 2 kg

  • 0 - 7 days: 10 mg/kg/day IV divided Q12H

  • > 7 days: 15 mg/kg/day IV divided Q8H

< 1.2 kg

  • 0 - 4 weeks: 10 mg/kg/day IV divided Q12H

General Information

First Line Indications

  • Toxic shock syndrome to inhibit toxin production
  • May be considered in combination with a beta-lactam antibiotic for treatment of confirmed abscesses of the head and neck as an alternative to metronidazole

Oral Liquids

Concentration: 15 mg/mL

Taste: Unpleasant taste

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

Tablet/Capsule Strengths

  • 150 mg

  • 300 mg

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.