Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$2-3/day (Oral)

General Information

First Line Indications

  • Prophylaxis or treatment of a human or animal bite wound

  • Children with AOM (BID or preferably TID) who have taken Amoxicillin in the prior 30 days

  • Those who have persistent AOM despite Amoxicillin therapy

  • Those for whom coverage for possible beta-lactamase positive H. influenzae and M. catarrhalis and/or S. aureus is required (e.g. chronic sinusitis)

Oral Liquids

Concentration: 400 mg/5 mL of 7:1 formulation

Taste: Good

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

Tablet/Capsule Strengths

  • 500 mg amoxicillin component

  • 875 mg amoxicillin component

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary