ESBL- Extended Spectrum Beta-Lactamase producing organisms

Precautions

Contact Precautions
Contact Precautions

General Information

Pathogen information

Gram negative organisms with enzymes that confer resistance to 3rd generation cephalosporins in addition to lower order beta-lactams.

Epidemiology

Generally, normal GI flora that have a plasmid encoding ESBL.

Community-acquired and nosocomial infections occur, especially if received antimicrobials or have travelled to areas of high prevalence (i.e. Asia/India).

Human-to-human transmission occurs and outbreaks have beed described.

Can also pick up from environment/water, surfaces, animals, and meat!

Associated syndromes

Asymptomatic colonization, or any syndrome caused by the organism carrying it (see the organism for list)

Additional Information

Contact Precautions to be discontinued only by IPAC

ESBLs vs. ampC: Most ESBLs are plasmid-encoded, whereas ampCs are usually inducible and chromosomal.

In the lab, ESBLs test susceptible to cefoxitin and cefotetan, and are inhibited by beta-lactamse inhibitors such as tazobactam. They test resistant to aztreonam.