General Susceptibility

MSSA: Anti-staphylococcal penicillins (i.e. cloxacillin) and cephalosporins (i.e. cefazolin) are optimal agents for intravenous therapy of MSSA infections.

MRSA: By definition resistant to cloxacillin and cephalosporins. Susceptible to vancomycin, daptomycin, and linezolid. Still generally susceptible to TMP-SMX and tetracyclines. Variable susceptibility to clindamycin, and erythromycin.