Antimicrobials
Voriconazole

Voriconazole

Low
Excellent
IV-$300 PO-$100

Spectrum of Activity

Dosing

General Information

Aspergillosis

  • Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity (discuss with ID). Target trough 1-6 mg/L.
  • Collect in heparinized red top tube 0-30 minutes prior to dose and send to Toronto Sick Kids for analysis
  • Monitor QTc interval in patients at elevated risk
  • Monitor hepatic profile
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash - up to 20%
  • GI upset
  • Visual disturbances may occur

Many via CYP450- suggest review interactions with pharmacist.

Risk when combining with other QTc prolonging agents

Antimicrobial class: Triazole antifungal, second generation

Average serum half life: Variable and dose dependent.

Route of Elimination: Urine (<2% as unchanged drug)