Antimicrobials
Quinine Sulfate

Quinine Sulfate

N/A
Excellent

Spectrum of Activity

Dosing

General Information

Alternative treatment for severe malaria (if artesunate is not available).

Oral preparation sometimes used to treat uncomplicated malaria as an alternative to artemisinin-based combination therapies.

Bolus injections of quinine are associated with dangerous hypotension

Pregnancy category: Used in the first trimester of pregnancy to treat uncomplicated falciparum malaria (combined with clindamycin)

Average serum half life: 9 to 18 hours

Metabolism: Quinine undergoes hepatic biotransformation to 3-hydroxyquinine and dihydroquinine. Unchanged drug is excreted via the kidney. Metabolism to the biologically active 3-hydroxyquinine increases with recovery from acute malaria.