Derivatives of tetracycline such as doxycycline and minocycline are more active with convenient dosing and therefore are used more often.
Pharmacology: Inhibits bacterial protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria.
Antimicrobial class: Tetracyclines
Pregnancy category: D
Average serum half life: 6 - 11 hours
Biliary penetration: 200 - 3200 % of plasma concentration
CSF penetration: Poor
Metabolism: Majority not metabolised and excreted in urine and faeces.
Route of Elimination: Renal: 30% GI: 20 - 60%