Hospital Formulary Status Yes (parenteral inj)
In-Hospital Cost will be updated
PharmaCare Formulary Status No
Special Authority None
PharmaCare Coverage None
Outpatient Cost 50mg powder for soln/inj - $77.14-84.85/vial
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.
Gastritis (IV)
Allergic skin reactions (IV)
Teeth and bone toxicity (IV)
Hepatotoxicity (IV)
Renal failure exacerbation (IV)
Jarisch-Herxheimer type reaction (IV)
Mortality (IV)
Other uncommon ADRs
Oral contraceptives less effective.
Antimicrobial class: Tetracycline Derivative
Pregnancy category: D
Requires Infectious Disease consultation.
Documented safety concerns in bacteremia especially.
Average serum half life: 42.0 hr
Lung penetration: Therapeutic
Biliary penetration: Therapeutic