Antimicrobials
Cefixime

Cefixime

Medium
N/A
See below under General Info

Spectrum of Activity

Dosing

General Information

Hospital Formulary Status Yes (PO solid, PO powder for susp)

In-Hospital Cost will be updated

PharmaCare Formulary Status Yes (PO solid, PO susp)

SA None

PharmaCare Coverage 400mg PO - $3.3966/tab 100mg/5ml PO susp recon - $0.4211/ml

Outpatient Cost 400mg PO - $3.56-4.95/tab 100mg/5ml PO susp recon - $0.42-0.46/ml

Susceptible gram negative infections when oral step down therapy preferred

Allergic reaction (PO)

  • IgE-mediated
  • sx: pruritus, flushing, urticaria, angioedema, wheezing, laryngeal edema, hypotension, and/or anaphylaxis
  • sx usually appear within 4 hrs of administration but may begin within mins

Serum sickness (PO)

  • late allergic reaction
  • sx: fever, rash, adenopathy, arthritis and glomerulonephritis
  • associated with circulating immune complexes

Rash (PO)

  • includes morbilliform rash, erythema multiforme, SJS, exfoliative dermatitis, toxic epidermal necrolysis and vasculitis
  • sx: photosensitivity, skin lesions, mucosal membrane ulceration, erythema, scaling, palpable purpura and/or positive Nikolsky's sign

Note: EBV-related rash - not an allergy

  • morbilliform rash, occurring 48 hrs to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus, does not appear to be a true drug allergy