Imipenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

General Information

Adverse Effects

Immediate and delayed-type allergy

GI disturbance

Cytopenias, positive Coombs

Liver enzyme abnormalities

CNS effects including confusional states and seizures

Major Interactions

May decrease serum concentrations of valproic acid

Ganciclovir/valganciclovir - may increase risk of seizures

Cyclosporine - may enhance neurotoxic effects of imipenem

Additional Information

Requires ID or Antimicrobial Stewardship approval for onging use without an accepted indication

Pharmacology

Antimicrobial class: Carbapenem

Average serum half life: 1.0