Imipenem - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

0 - 30 eGFR

500mg q12h

30 - 50 eGFR

500mg IV q8h

50+ eGFR

500mg IV q6h

250-500mg IV q12h

500mg IV q8h