5-10mg/kg IV q8h 10mg/kg IV q8h for serious infections such as CNS and disseminated zoster 800mg PO 5 times per day for shingles Prophylaxis dosing varies by indication
Therapy for herpes viral infections (HSV and VZV) including encephalitis
Prophylaxis of herpes viral infections if recurrent disease or immunocompromised
Follow SCr as appropriate, check urine for crystals if suspect AKI
GI upset, phlebitis- common
AKI from crystal nephropathy
Mycophenolate can increase the acyclovir concentration
May diminish efficacy of zoster or varicella vaccine
For oral indications, consider Valacyclovir (pro-drug) which is more bioavailable with more convenient dosing.
IV normal saline recommended to prevent crystal nephropathy.
Antimicrobial class: Antiviral, nucleoside analogue
Pregnancy category: B
Average serum half life: 3.0
Urine penetration: Therapeutic
CSF penetration: Therapeutic