Acyclovir
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (EGFR)

0 - 10 eGFR

2.5-5mg/kg IV q24h

10 - 25 eGFR

5-10mg/kg IV q24h

25 - 50 eGFR

5-10mg/kg IV q12h

50+ eGFR

5-10mg/kg IV q8h

Intermittent Dialysis

2.5-5 mg/kg IV q24h post dialysis on IHD days (higher dose for CNS infection)

Continuous Dialysis

5-7.5mg/kg IV q24h. Use upper end for CNS infections