Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

Dosing

875mg PO BID or 500mg PO TID of the amoxicillin component

General Information

Common Usage

Prophylaxis/treatment of bite wounds

Polymicrobial infections of the respiratory tract or abdomen

Skin and soft tissue infections

Drug Monitoring

For prolonged therapy monitor liver enzymes, CBC

Adverse Effects

Hepatotoxicity due to calvulanate- usually mild, liver failure is rare

Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic