C. diff Risk


Oral Bioavailability


Approximate Cost


875mg PO BID or 500mg PO TID of the amoxicillin component

General Information

Common Usage

Prophylaxis/treatment of bite wounds

Polymicrobial infections of the respiratory tract or abdomen

Skin and soft tissue infections

Drug Monitoring

For prolonged therapy monitor liver enzymes, CBC

Adverse Effects

Hepatotoxicity due to calvulanate- usually mild, liver failure is rare

Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash

Major Interactions

Increased risk of rash with allopurinol


Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic