0.3-1.5mg/kg IV daily, infused over several hours. Must be approved by Infectious Disease.
Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity
Induction therapy for dimorphic fungii (cocci, blasto, histo)
Renal function, K, Mg, HCO3, liver enzymes, CBC.
Frequency depends on course, but daily reasonable during initiation
Infusion related symptoms: fever/rigors/N/V/headache (see additional information)
Electrolyte abnormalities - hypoK and hypoMg, loss of bicarb (see additional information re: electrolyte infusions)
Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy
Digoxin - increased digoxin toxicity with hypokalemia
Infectious Disease to approve use.
Careful attention to electrolyte and fluid status with boluses (usually 500mL) of NS before and after infusion, as well as K and Mg supplementation PRN
Antimicrobial class: Antifungal - polyene
Pregnancy category: B
Average serum half life: 24.0
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic