Aztreonam

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

2g IV q8h for severe infections

General Information

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent

Nebulized form used in cystic fibrosis patients

Empiric therapy for febrile neutropenia

Drug Monitoring

Monitor liver enzymes

Adverse Effects

Elevated liver enzymes, cytopenias, eosinophilia, phlebitis at injection site, rash/allergy, CNS toxicity

Major Interactions

No significant

Pharmacology

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate