Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

2 g IV q8h

General Information

Common Usage

Skin and soft tissue infection (i.e. cellulitis), bone and joint infections, endocarditis

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Major Interactions

Probenecid prolongs half-life. Drug interaction has been used therapeutically to give once daily cefazolin

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic