Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Dosing

2g IV q8-12h

General Information

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms.

Empiric treatment of febrile neutropenia

Adverse Effects

Allergy (immediate & delayed), positive Coombs, cytopenias, non-convulsive status epilepticus

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic