Cefepime - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

0 - 10 eGFR

1g IV q24h

10 - 30 eGFR

2g IV q24h

30 - 60 eGFR

2g IV q12h

60+ eGFR

2g IV q8h

1g IV q24h, dose post-HD on dialysis days

2g IV q8h