Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Dosing

Ceftriaxone Usual Dose 1-2 gm IV q24h

Bacterial meningitis 2 gm IV q12h

Enterococcus faecalis endocarditis 2g IV q12h

General Information

Common Usage

Empiric therapy of bacterial meningitis

Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)

Empiric therapy of hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Empiric therapy of spontaneous bacterial peritonitis

Empiric treatment of pyelonephritis

Adverse Effects

Allergy/rash (immediate or delayed).

Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities

Pseudocholelithiasis- unclear clinical significance - uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic