Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

Dosing

750-1500mg IV q8h 500mg po BID

General Information

Common Usage

Community acquired pneumonia; pharyngitis/tonsillitis; sinusitis; acute exacerbations of chronic bronchitis; COPD

Adverse Effects

Allergy (immediate & delayed), positive Coombs, cytopenias, GI upset, diarrhea, abnormal liver enzymes

Major Interactions

None significant

Additional Information

Due to poor oral bioavailability, tablet should be given with food to increase absorption

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic