Cefuroxime
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis: PO Dosing (EGFR)

0 - 30 eGFR

No dose adjustment required

30+ eGFR

500mg PO BID

Not On Dialysis: IV Dosing (EGFR)

0 - 25 eGFR

750-1500mg IV q12-24h

25 - 50 eGFR

750-1500mg IV q8-12h

50+ eGFR

750-1500mg IV q8h

Intermittent Dialysis

IV: 750-1500mg IV q24h, give dose after HD on dialysis days Oral: 500mg PO BID

Continuous Dialysis

750-1500mg IV q12h