In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.
If worsening renal function, actual GFR is likely lower than calculated.
If improving renal function, actual GFR is likely higher than calculated eGFR.
0 - 30 eGFR
500mg PO daily
500mg PO BID
500mg PO daily, dose after dialysis on HD days
CRRT dose NA