300-450mg IV q8h for usual indications 900mg IV q8h for necrotizing skin/soft tissue infections or toxic shock syndrome 300-450mg PO TID
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
None specific - monitor for diarrhea.
High risk of Clostridium difficile infection
Muscle relaxants, e.g., atracurium, baclofen, diazepam
St. Johns Wort
Antimicrobial class: Lincosamide
Pregnancy category: B
Average serum half life: 2.4
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor