Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

2g IV q4-6h

General Information

Common Usage

Treatment of MSSA infections

Adverse Effects

Allergy (immediate or delayed), Phlebitis at injection site in a peripheral vein, cytopenias, eosinophilia, interstitial nephritis, abnormal liver enzymes

Major Interactions

Can increase methotrexate levels

Decrease mycophenolate levels

Additional Information

Must use higher doses in bacteremia due to highly protein bound

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic