Daptomycin - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

0 - 30 eGFR

Give dose q48h

50+ eGFR

Regular dosing

Give dose after HD on dialysis days

8mg/kg IV q48h