Ertapenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

1g IV q24h

General Information

Common Usage

Targeted therapy of ESBL infections and other resistant gram negative infections

Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity

Adverse Effects

Immediate and delayed-type allergy

GI disturbance

Cytopenias, eosinophilia, positive Coombs

Liver enzyme abnormalities

Seizure risk lower than other carbapenems

Additional Information

At PHC, restricted to outpatient or ambulatory setting with ID approval

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate