Fosfomycin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Dosing

Female, uncomplicated cystitits: 3g PO once Complicated or male cystitits: 3g PO q2-3days x 3 doses

Dose post-hemodialysis

General Information

Common Usage

Cystitis, especially involving ESBL producing organisms

Adverse Effects

  • GI upset, especially diarrhea

  • ┬áHeadache

Major Interactions

No significant

Additional Information

Cannot be used for treatment of pyelonephritis.
At PHC, susceptibility testing will only be performed on E coli urine isolates. If fosfomyicn susceptibility is not released, call microbiology lab for more information.
IV formulation not available at this time.

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6.0

Urine penetration: Therapeutic