Meropenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

500mg IV q6h Meningitis: 2g IV q8h

General Information

Common Usage

Therapy of serious, often nosocomial infections involving resistant gram negative organisms

Adverse Effects

Immediate and delayed-type allergy

GI disturbance, cytopenias, positive Coombs

Liver enzyme abnormalities

Major Interactions

Valproic acid - carbapenems decrease valproate levels and may decrease seizure threshold

Additional Information

Requires ID or Antimicrobial Stewardship approval for onging use without an accepted indication

Pharmacology

Antimicrobial class: carbapenem

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic