Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Dosing

Cystitis: Macrobid 100mg PO BID

General Information

Common Usage

Uncomplicated cystitis with CrCl >40ml/min

Adverse Effects

Interstitial pneumonitis and fibrosis especially with prolonged use

Peripheral neuropathy

Major Interactions

Antacids decrease absorption

Additional Information

Cannot be used for treatment of pyelonephritis

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic