Antimicrobials
Oseltamivir

Oseltamivir

None
Excellent

Spectrum of Activity

Dosing

General Information

Treatment and prophylaxis of influenza A and B

Pregnancy:

  • Compatible.
  • Reports describing the use of oseltamivir during human pregnancy do not suggest a significant risk of developmental toxicity.
  • Influenza infection in pregnancy is a high-risk condition, the maternal benefit far outweighs the unknown risk, if any, to the embryo or fetus.

Breastfeeding:

  • Compatible.
  • Oseltamivir and its active metabolite are poorly excreted into breastmilk.
  • Maternal dosages of 150 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants.
  • Therapeutic doses of oseltamivir are given to newborns with influenza.
  • GI upset common
  • Rare - Stevens Johnson
  • Neuropsychiatric side effects reported

No significant

Will only treat Influenza A and B. Does NOT treat RSV, parainfluenza, human metapneumovirus, adenovirus, or other common viral pathogens Higher doses have not been shown to be superior, but may be considered in critically ill or obese patients i.e. 150mg PO BID

Antimicrobial class: Antiviral - neuraminidase inhibitor

Average serum half life: 2.0

Lung penetration: Therapeutic