Oseltamivir
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis: Treatment (EGFR)

10 - 30 eGFR

30mg PO daily x 5 days

31 - 60 eGFR

75mg PO daily x 5 days

or

30mg PO BID x 5 days

60+ eGFR

75mg PO BID x 5 days

Not On Dialysis: Prophylaxis (EGFR)

10 - 30 eGFR

30mg PO every other day until outbreak is over

31 - 60 eGFR

30mg PO daily until outbreak is over

60+ eGFR

75mg PO daily until outbreak is over

Intermittent Dialysis

Treatment

30mg PO on day 1, then 30mg PO after each HD for 5 days

Prophylaxis

30mg PO on day 1, then 30mg PO after each HD until outbreak is over

Continuous Dialysis

Treatment

75mg PO daily x 5 days

Prophylaxis

75mg PO every other day until outbreak is over