Oseltamivir - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

10 - 30 eGFR

30mg PO every other day until outbreak is over

31 - 60 eGFR

30mg PO daily until outbreak is over

60+ eGFR

75mg PO daily until outbreak is over

10 - 30 eGFR

30mg PO daily x 5 days

31 - 60 eGFR

30mg BID x 5 days

60+ eGFR

75mg PO BID x 5 days

TREATMENT: 30mg po on DAY 1, then 30mg po after each HD for 5 days
PROPHYLAXIS: 30mg po on DAY 1, then 30mg po after each HD until outbreak is over

Treatment: 75mg PO daily x 5 days
Prophylaxis: 75mg PO every other day until outbreak is over