Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

3.375 IV q6h Severe Pseudomonas infections: 4.5g IV q6h

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia

Adverse Effects

Allergy/rash (immediate or delayed), cytopenias- esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes

Major Interactions

Incr. levels of methotrexate

Additional Information

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Pharmacology

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic