Piperacillin-Tazobactam
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (EGFR)

0 - 30 eGFR

2.25g IV q6h

30 - 50 eGFR

3.375g IV q6h

50+ eGFR

3.375-4.5g IV q6h

Intermittent Dialysis

2.25g IV q8h

Continuous Dialysis

3.375g IV q6h