Clostridium difficile is the commonest cause of infectious diarrhea in hospitals.
Implement contact precautions for suspected or confirmed C.difficile infection (CDI).
For all patients with CDI, discontinue concurrent antibiotics, proton pump inhibitors (PPIs), anti-peristaltic and promotability agents unless these are required. The reason for continuing these medications should be documented.
Medical and surgical management of CDI is based on severity of illness.
Diarrhea (more than 3 unformed or watery stools in 24 hours)
Pending C.difficile test with high clinical suspicion
Indeterminate C. difficile test
Positive C.difficile test
Endoscopic or histologic evidence of pseudomembranous colitis