Monotherapy of gram positive or anaerobic infections
Order appropriate trough level for dosage regimen being used
Once Daily/Extended Interval Dosing
Multiple Daily Dosing
Gentamicin Peaks
Nephrotoxicity
KEEP DURATION TO MINIMUM POSSIBLE FOR INDICATION BEING TREATED
Vestibulocochlear toxicity
Other
Increased nephrotoxicity
Increased ototoxicity
Non-depolarizing muscle relaxants may be potentiated
IV Administration: Dilute in 100 mL D5W or NS and administer over 30-60 min. (60 min for extended interval dosing)
A typical Hemodialysis may remove up to 50% of gentamicin. As such pre-dialysis levels of 1.5 to 3 mg/L are considered acceptable in this population.
N/A
Antimicrobial class: Aminoglycoside
Pregnancy category: D
Average serum half life: 2 hours
Biliary penetration: Moderate
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic