Antimicrobials
Fosfomycin

Fosfomycin

Low
Low (20 to 40%)
$26.10/dose

Spectrum of Activity

Dosing

General Information

Treatment of uncomplicated cystitis

  • Pyelonephritis
  • Bacteremia
  • Urosepsis
  • Perinephric abscess
  • Uncomplicated Urinary Tract Infection, especially involving ESBL producing organisms
  • Offlabel: Prostatitis, complicated UTI
  • GI upset, especially diarrhea
  • Headache
  • Eosinophilia, neutropenia
  • Hypokalemia

No significant interactions

For cystitis only. Do not use in pyelonephritis or urosepsis/bacteremia

NLPDP Status: Special Authorization required (see more Information)

Supplied as 3g powder in sachet; dissolve in 3-4 oz fluid

Can be given PO or via NG tube

Bioavailability < 40% however achieves high concentrations for prolonged period in urine

SPECIAL AUTHORIZATION REQUIRED

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic