Ertapenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

Requires Infectious Disease consultation for use OR completion of the Restricted Antimicrobial order form for approved indications 1 gm IV every 24 hr

General Information

Acceptable Uses

ESBL+ E.coli and Klebsiella infections (intra-abdominal, skin and soft tissue, complicated urinary tract, and pneumonia)

Unacceptable Uses

  • Empiric therapy

  • Infections in which Psuedomonas or Acinetobacter are suspected

Common Usage

  • Targeted therapy of ESBL infections and other resistant gram negative infections.

Drug Monitoring

Lab

  • periodic SCr and LFTs

Clinical

  • Hypersenisitivty

  • GI effects

  • seizures (rare)

Adverse Effects

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, eosinophilia, positive Coombs

  • Liver enzyme abnormalities

  • Seizure risk lower than other carbapenems

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate