Ertapenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

Dosing

Requires Infectious Disease consultation for use OR completion of the Restricted Antimicrobial order form for approved indications

1 gm IV every 24 hr

General Information

Acceptable Uses

ESBL+ E.coli and Klebsiella infections (intra-abdominal, skin and soft tissue, complicated urinary tract, and pneumonia)

Unacceptable Uses

  • Empiric therapy

  • Infections in which Psuedomonas or Acinetobacter are suspected

Common Usage

  • Targeted therapy of ESBL infections and other resistant gram negative infections.

Drug Monitoring

Lab

  • periodic SCr and LFTs

Clinical

  • Hypersenisitivty

  • GI effects

  • seizures (rare)

Adverse Effects

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, eosinophilia, positive Coombs

  • Liver enzyme abnormalities

  • Seizure risk lower than other carbapenems

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic