Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Dosing

Usual Dose - 1-2 g IV every 24 hr

Bacterial meningitis - 2 g IV every 12 hr

General Information

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  •  Nosocomial gram negative infections (except Pseudomonas)

  •  Spontaneous bacterial peritonitis

  •  Hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Drug Monitoring

Clinical

  • Hypersensitivity

  • Diarrhea

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

  •  Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic