Usual indications 600 mg IV every 8 hr Necrotizing SSTI or toxic shock syndrome 900mg IV every 8 hr Oral Dosing 300 - 450mg PO every 6 hr
Anaerobic infections below the diaphragm
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
Monitor for diarrhea
Muscle relaxants, e.g., atracurium, baclofen, diazepam.
St. Johns Wort
Antimicrobial class: Lincosamide
Pregnancy category: B
Average serum half life: 2.4 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor