Clindamycin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

Dosing

Usual indications
600 mg IV every 8 hr

Necrotizing SSTI or toxic shock syndrome
900mg IV every 8 hr

Oral Dosing
300 - 450mg PO every 6 hr

General Information

Unacceptable Uses

Anaerobic infections below the diaphragm

Common Usage

Anaerobic infections above the diaphragm, especially dental infection.

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

Drug Monitoring

Clinical
Monitor for diarrhea

Adverse Effects

  • Diarrhea

  • C. difficile

Major Interactions

Muscle relaxants, e.g., atracurium, baclofen, diazepam.

St. Johns Wort

Pharmacology

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor