Vancomycin PO

C. diff Risk


Oral Bioavailability


Approximate Cost

Spectrum Of Activity


125 mg PO/NG/OG every 6 hr for 10-14 days

Life-threatenting infections, ileus
500 mg PO/NG/OG every 6 hr for 10-14 days

Intra-colonic dose
250 mg in 100mL of NS by rectal enema every 6 hr

General Information

Common Usage

Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease

Drug Monitoring


  • Possibility of accumulation in severe renal dysfunction.

  • Consider checking a vancomycin level in dialysis patients.

Additional Information

No oral absorption.

May increase vancomycin resistant Enterococci colonization in the gut.


Antimicrobial class: Glycopeptide

Pregnancy category: B

Average serum half life: 0 hours

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: None