Penicillin G

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Dosing

12-24 million units/day IV in divided doses every 4-6 hr
(2-4 million units IV every 4 hr)

Latent or secondary Syphillis
2.4 million units IM weekly x 3 doses

General Information

Common Usage

Therapy of Streptococcal and other documented susceptible infections.

Drug Monitoring

Lab

  • periodic CMP and CBC

Clinical

  • Hypersensitivity

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic