Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Dosing

2 g every 8-12 hr

General Information

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Drug Monitoring

Lab

  • monitor renal function

Clinical

  • Hypersensitivity

Adverse Effects

  • Allergy (immediate & delayed)

  • ¬†Positive Coombs

  • ¬†GI effects/Diarrhea

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

Lung penetration: Therapeutic